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Tilomisole

Name: Tilomisole
Brand: TargetMol
SKU: T61107
Price: 162 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61107Cas No. 58433-11-7

Alias Wy 18251

Tilomisole (Wy 18251) is an orally available benzimidazole thiazole with anti-inflammatory activity and immunomodulatory activity.Tilomisole is used in the study of cancer and inflammation.

Tilomisole

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Purity: 99.21%

Catalog No. T61107Alias Wy 18251Cas No. 58433-11-7

Tilomisole (Wy 18251) is an orally available benzimidazole thiazole with anti-inflammatory activity and immunomodulatory activity.Tilomisole is used in the study of cancer and inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$162	In Stock	In Stock
5 mg	$390	In Stock	In Stock
10 mg	$590	In Stock	In Stock
25 mg	$943	In Stock	In Stock
50 mg	$1,280	In Stock	In Stock
100 mg	$1,730	-	In Stock
500 mg	$3,460	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tilomisole (Wy 18251) is an orally available benzimidazole thiazole with anti-inflammatory activity and immunomodulatory activity.Tilomisole is used in the study of cancer and inflammation.
In vitro	Tilomisole (100 μg/ml) was restored to normal the defective factor production by RA T cells. Indomethacin (1 microgram/ml) but not levamisole (0.1-100 μg/ml) had a similar effect, which suggests that the action of tilomisole in this system is due to its ability to inhibit prostaglandin biosynthesis. Nonetheless, the ability of tilomisole to down-regulate B cell function may contribute to the compound's antiarthritic activity.[3]
Synonyms	Wy 18251

Chemical Properties

Molecular Weight	342.8
Formula	C₁₇H₁₁ClN₂O₂S
Cas No.	58433-11-7
Smiles	C(C(O)=O)C1=C(N2C(S1)=NC=3C2=CC=CC3)C4=CC=C(Cl)C=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (145.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9172 mL	14.5858 mL	29.1715 mL	145.8576 mL
5 mM	0.5834 mL	2.9172 mL	5.8343 mL	29.1715 mL
10 mM	0.2917 mL	1.4586 mL	2.9172 mL	14.5858 mL
20 mM	0.1459 mL	0.7293 mL	1.4586 mL	7.2929 mL
50 mM	0.0583 mL	0.2917 mL	0.5834 mL	2.9172 mL
100 mM	0.0292 mL	0.1459 mL	0.2917 mL	1.4586 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc