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BMS-688521

Name: BMS-688521
Brand: TargetMol
SKU: T14676
Price: 116 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14676Cas No. 893397-44-9

BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.

BMS-688521

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Purity: 98.87%

Catalog No. T14676Cas No. 893397-44-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$116	-	In Stock
5 mg	$293	-	In Stock
10 mg	$413	-	In Stock
25 mg	$738	-	In Stock
50 mg	$972	-	In Stock
100 mg	$1,180	-	In Stock
200 mg	$1,580	-	In Stock
1 mL x 10 mM (in DMSO)	$346	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.
Targets&IC50	ICAM1:78 nM
In vitro	BMS-688521 inhibits the specific adhesion of mouse splenocytes and a mouse ICAM-1 expressing cell line, b.END3, with an IC50 of 78 nM[1].
In vivo	In BALB/c female mice, 6-8 weeks of age (OVA Lung Inflammation in Mice), BMS-688521 (1, 3, and 10 mg/kg; p.o.; BID for three days) exhibited significant inhibition of eosinophil accumulation at a dose of 1 mg/kg BID, with dose-dependent inhibition observed at 3 mg/kg and 10 mg/kg[1].

Chemical Properties

Molecular Weight	536.37
Formula	C₂₆H₁₉Cl₂N₅O₄
Cas No.	893397-44-9
Smiles	O=C1[C@@]2([C@@H](CN(C2)C3=CC=C(C(O)=O)C=N3)C4=CC=C(C#N)C=C4)N(C)C(=O)N1C5=CC(Cl)=CC(Cl)=C5
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (149.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (9.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8644 mL	9.3219 mL	18.6438 mL	93.2192 mL
5 mM	0.3729 mL	1.8644 mL	3.7288 mL	18.6438 mL
10 mM	0.1864 mL	0.9322 mL	1.8644 mL	9.3219 mL
20 mM	0.0932 mL	0.4661 mL	0.9322 mL	4.6610 mL
50 mM	0.0373 mL	0.1864 mL	0.3729 mL	1.8644 mL
100 mM	0.0186 mL	0.0932 mL	0.1864 mL	0.9322 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc