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GLPG3970

Name: GLPG3970
Brand: TargetMol
SKU: T73384
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T73384Cas No. 2403733-82-2

GLPG3970 GLPG3970 is a novel orally available selective dual SIK2/SIK3 inhibitor.GLPG3970 has potential anti-inflammatory activity for the study of autoimmune diseases.

GLPG3970

🥰Excellent

Purity: 99.63%

Catalog No. T73384Cas No. 2403733-82-2

GLPG3970 GLPG3970 is a novel orally available selective dual SIK2/SIK3 inhibitor.GLPG3970 has potential anti-inflammatory activity for the study of autoimmune diseases.

Pack Size	Price	Availability
1 mg	$60	In Stock
5 mg	$139	In Stock
10 mg	$198	In Stock
25 mg	$416	In Stock
50 mg	$625	In Stock
100 mg	$890	In Stock
200 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.63%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GLPG3970 GLPG3970 is a novel orally available selective dual SIK2/SIK3 inhibitor.GLPG3970 has potential anti-inflammatory activity for the study of autoimmune diseases.
Targets&IC50	SIK1:282.8 nM, SIK2:7.8 nM, SIK3:3.8 nM

Chemical Properties

Molecular Weight	504.5
Formula	C₂₅H₂₇F₃N₄O₄
Cas No.	2403733-82-2
Smiles	O=C1C=2C(OC)=CC(=CC2CCN1CC(F)(F)F)C3=CN=C4C=C(OCCN5CCOCC5)C=CN43

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 128.8 mg/mL (255.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9822 mL	9.9108 mL	19.8216 mL	99.1080 mL
5 mM	0.3964 mL	1.9822 mL	3.9643 mL	19.8216 mL
10 mM	0.1982 mL	0.9911 mL	1.9822 mL	9.9108 mL
20 mM	0.0991 mL	0.4955 mL	0.9911 mL	4.9554 mL
50 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9822 mL
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc