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DSRM-3716

Name: DSRM-3716
Brand: TargetMol
SKU: T8860
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8860Cas No. 58142-99-7

Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

DSRM-3716

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Purity: 99.78%

Catalog No. T8860Cas No. 58142-99-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$45	In Stock	In Stock
100 mg	$72	In Stock	In Stock
200 mg	$97	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.78%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
Targets&IC50	CADPR increase:2.8 μM, SARM1:75 nM
In vitro	Treatment with the isoquinoline DSRM-3716produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. DSRM-3716prevented NfL release from severed axons in a dose-dependent manner[1].

Chemical Properties

Molecular Weight	255.06
Formula	C₉H₆IN
Cas No.	58142-99-7
Smiles	IC1=CC=CC2=CN=CC=C12
Relative Density.	1.837 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (196.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9206 mL	19.6032 mL	39.2065 mL	196.0323 mL
5 mM	0.7841 mL	3.9206 mL	7.8413 mL	39.2065 mL
10 mM	0.3921 mL	1.9603 mL	3.9206 mL	19.6032 mL
20 mM	0.1960 mL	0.9802 mL	1.9603 mL	9.8016 mL
50 mM	0.0784 mL	0.3921 mL	0.7841 mL	3.9206 mL
100 mM	0.0392 mL	0.1960 mL	0.3921 mL	1.9603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc