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AR-C155858

Name: AR-C155858
Brand: TargetMol
SKU: T14316
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14316Cas No. 496791-37-8

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

AR-C155858

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Purity: 99.42%

Catalog No. T14316Cas No. 496791-37-8

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$517	In Stock	In Stock
25 mg	$843	In Stock	In Stock
50 mg	$1,160	-	In Stock
100 mg	$1,570	-	In Stock
1 mL x 10 mM (in DMSO)	$312	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.42%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).
Targets&IC50	MCT2:10 nM(ki), MCT1:(ki)2.3 nM
In vitro	AR-C155858, at concentrations ranging from 10 nM to 100 nM, effectively inhibits the activity of MCT1/MCT2 C-terminal chimeras[1]. This compound also demonstrates time- and concentration-dependent inhibition of MCT1 when expressed in Xenopus oocytes[2]. Furthermore, AR-C155858 exhibits an inhibitory effect on MCT2, achieving 70% inhibition at 10 nM, with inhibition levels increasing gradually, indicative of a dissociation constant (Ki) value significantly lower than 10 nM.

Chemical Properties

Molecular Weight	461.53
Formula	C₂₁H₂₇N₅O₅S
Cas No.	496791-37-8
Smiles	CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O
Relative Density.	1.395 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (86.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1667 mL	10.8335 mL	21.6671 mL	108.3353 mL
5 mM	0.4333 mL	2.1667 mL	4.3334 mL	21.6671 mL
10 mM	0.2167 mL	1.0834 mL	2.1667 mL	10.8335 mL
20 mM	0.1083 mL	0.5417 mL	1.0834 mL	5.4168 mL
50 mM	0.0433 mL	0.2167 mL	0.4333 mL	2.1667 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc