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UNC10217938A
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Catalog No. T13254Cas No. 1347749-97-6
UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.
UNC10217938A
😃Good
Catalog No. T13254Cas No. 1347749-97-6
UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,298 | 1-2 weeks | 1-2 weeks | |
| 50 mg | $1,939 | 1-2 weeks | 1-2 weeks | |
| 100 mg | $2,909 | 1-2 weeks | 1-2 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects. |
| In vitro | When UNC10217938A is used in the range of 5-25 μM, it can significantly enhance the induction of luciferase in HelaLuc705 cells, and it is more effective and more effective than Retro-1. Compared to a separate splice switch oligonucleotide (SSO), UNC10217938A provids a 60-fold enhancement at 10 μM and 220-fold at 20 μM, in contrast to a 11-fold enhancement for 100 μM Retro-1. UNC10217938A can substantially enhance effects of receptor targeted oligonucleotide conjugates. UNC10217938A can also enhance the effect of uncharged morpholino oligonucleotides and negatively charged oligonucleotides . Exposure of cells to UNC10217938A caused a significant reduction in the colocalization of TAMRA-oligonucleotides with the late ribosomal marker Rab7, but had little effect on the colocalization with the lysosomal marker LAMP-1. UNC10217938A causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation. |
| Molecular Weight | 456.54 |
| Formula | C26H28N6O2 |
| Cas No. | 1347749-97-6 |
| Smiles | CCOC(=O)Nc1cc(NCCN(C)C)c2nc(-c3ccccc3)c(nc2n1)-c1ccccc1 |
| Relative Density. | 1.247 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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