Anti-neuroinflammation agent 1

Name: Anti-neuroinflammation agent 1
Brand: TargetMol
SKU: T79590
Rating: 4.5 (1 reviews)

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Catalog No. T79590

Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].

Anti-neuroinflammation agent 1

😃Good

Catalog No. T79590

Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Backorder	Backorder
50 mg	Inquiry	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].
In vitro	Anti-neuroinflammation agent 1 (BMP 29) exhibited enhanced anti-neuroinflammatory activity without toxicity to BV2 microglial cells. In LPS-stimulated BV2 microglia, it significantly reduced M1 phenotype microglia, increased M2 phenotype, decreased pro-inflammatory cytokines (IL-18, IL-1β, TNF-α), increased anti-inflammatory cytokine (IL-10), inhibited NLRP3 inflammasome formation, and downregulated the M2 isoform of pyruvate kinase [1].
In vivo	In mice, Anti-neuroinflammation Agent 1 (BMP 29) mitigates cuprizone-induced inflammation and demyelination by reducing the expression of inducible nitric oxide synthase, while simultaneously increasing the expression of CD206 [1].

Chemical Properties

Molecular Weight	523.86
Formula	C₂₂H₂₀ClF₆N₃O₃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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