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RJW100

🥰Excellent
Catalog No. T38680Cas No. 1276664-20-0

RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

RJW100

RJW100

🥰Excellent
Purity: 99.15%
Catalog No. T38680Cas No. 1276664-20-0
RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.
Pack SizePriceAvailabilityQuantity
1 mg$247In Stock
5 mg$595In Stock
10 mg$862In Stock
25 mg$1,270In Stock
1 mL x 10 mM (in DMSO)$616In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.15%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.
In vitro
RJW100 (compound 24-exo) treatment significantly increases small/short heterodimer partner (SHP) transcripts in a dose-dependent manner starting at 5 µM. It almost completely displaces bound PIP2 phospholipid from SF-1 at 1 µM. Using hLRH-1 LBD alone without any phospholipids, a clear dose-dependent shift in hLRH-1 LBD native PAGE migration is observed with RJW100 (compound 24-exo; 0-100 µM) binding[1]. RJW100 strongly activates the miR-200c promoter and effectively downregulates ZEB1 and ZEB2 proteins[2].
Chemical Properties
Molecular Weight386.57
FormulaC28H34O
Cas No.1276664-20-0
SmilesC(=C)([C@]12C(=C(CCCCCC)C[C@]1([C@H](O)CC2)[H])C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.1.064 g/cm3 (Predicted)
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (142.28 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5869 mL12.9343 mL25.8685 mL129.3427 mL
5 mM0.5174 mL2.5869 mL5.1737 mL25.8685 mL
10 mM0.2587 mL1.2934 mL2.5869 mL12.9343 mL
20 mM0.1293 mL0.6467 mL1.2934 mL6.4671 mL
50 mM0.0517 mL0.2587 mL0.5174 mL2.5869 mL
100 mM0.0259 mL0.1293 mL0.2587 mL1.2934 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

steroidogenic factor-1 (SF-1, NR5A1)RJW-100RJW100RJW 100liver receptor homolog-1 (LRH1, NR5A2)
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