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SIB-1553A hydrochloride

Name: SIB-1553A hydrochloride
Brand: TargetMol
SKU: T16881
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16881Cas No. 191611-89-9

SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment.

SIB-1553A hydrochloride

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Purity: 99.73%

Catalog No. T16881Cas No. 191611-89-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	-	In Stock
2 mg	$83	-	In Stock
5 mg	$141	-	In Stock
10 mg	$227	-	In Stock
25 mg	$376	-	In Stock
50 mg	$530	-	In Stock
100 mg	$713	-	In Stock
200 mg	$962	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:Yellow

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COA HNMR IC LCMS ORP

Product Introduction

Bioactivity

Description	SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment.
In vitro	In calcium flux assays, compared to nicotine, SIB-1553A hydrochloride (0.1-5 μM) exhibits higher selectivity in both potency and efficacy towards β4 subunits containing recombinant hnAChRs (α2β4, α3beta4, and α4β4) over β2 subunits containing nAChRs (α4β2 and α3beta2)[1].
In vivo	In Male Sprague-Dawley rats (200-250 g), SIB-1553A hydrochloride (1, 2, 4, 10, 20, and 40 mg/kg; s.c) induced hippocampal ACh release[2].

Chemical Properties

Molecular Weight	273.82
Formula	C₁₃H₂₀ClNOS
Cas No.	191611-89-9
Smiles	Cl.CN1CCCC1CCSc1ccc(O)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (73.04 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.6520 mL	18.2602 mL	36.5203 mL	182.6017 mL
5 mM	0.7304 mL	3.6520 mL	7.3041 mL	36.5203 mL
10 mM	0.3652 mL	1.8260 mL	3.6520 mL	18.2602 mL
20 mM	0.1826 mL	0.9130 mL	1.8260 mL	9.1301 mL
50 mM	0.0730 mL	0.3652 mL	0.7304 mL	3.6520 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc