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MeAIB

Name: MeAIB
Brand: TargetMol
SKU: T40194
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40194Cas No. 2566-34-9

Alias α-(Methylamino)isobutyric acid

MeAIB is an N-acetyltransferase inhibitor that inhibits SNAT2-related signaling pathways. MeAIB is a specific substrate for amino acid transport system a (ATA1). Amino acid transport system a (ATA1) regulates the uptake of short chain neutral amino acids by Na+ flow.

MeAIB

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Purity: 99.82%

Catalog No. T40194Alias α-(Methylamino)isobutyric acidCas No. 2566-34-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MeAIB is an N-acetyltransferase inhibitor that inhibits SNAT2-related signaling pathways. MeAIB is a specific substrate for amino acid transport system a (ATA1). Amino acid transport system a (ATA1) regulates the uptake of short chain neutral amino acids by Na+ flow.
In vitro	ATA3 is a novel subtype of amino acid transport system A, which is mainly presented in liver and skeletal muscle. ATA1(also known as GlnT) and ATA2(also known as SAT2) have been cloned from rat and human tissues. These transporters control the uptake of short chain neutral amino acids in a Na + dependent manner [1] .
Synonyms	α-(Methylamino)isobutyric acid

Chemical Properties

Molecular Weight	117.15
Formula	C₅H₁₁NO₂
Cas No.	2566-34-9
Smiles	CNC(C)(C)C(O)=O
Relative Density.	1.2000 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (384.12 mM), when pH is adjusted to 2 with 1M HCl. Sonication and heating to 60℃ are recommended.

H2O: 166.7 mg/mL (1422.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (17.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	8.5361 mL	42.6803 mL	85.3606 mL	426.8032 mL
5 mM	1.7072 mL	8.5361 mL	17.0721 mL	85.3606 mL
10 mM	0.8536 mL	4.2680 mL	8.5361 mL	42.6803 mL
20 mM	0.4268 mL	2.1340 mL	4.2680 mL	21.3402 mL
50 mM	0.1707 mL	0.8536 mL	1.7072 mL	8.5361 mL
100 mM	0.0854 mL	0.4268 mL	0.8536 mL	4.2680 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc