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MeAIB

Name: MeAIB
Brand: TargetMol
SKU: T40194
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40194Cas No. 2566-34-9

Alias α-(Methylamino)isobutyric acid

MeAIB is an N-acetyltransferase inhibitor that inhibits SNAT2-related signaling pathways. MeAIB is a specific substrate for amino acid transport system a (ATA1). Amino acid transport system a (ATA1) regulates the uptake of short chain neutral amino acids by Na+ flow.

MeAIB

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Purity: 99.78%

Catalog No. T40194Alias α-(Methylamino)isobutyric acidCas No. 2566-34-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.78%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MeAIB is an N-acetyltransferase inhibitor that inhibits SNAT2-related signaling pathways. MeAIB is a specific substrate for amino acid transport system a (ATA1). Amino acid transport system a (ATA1) regulates the uptake of short chain neutral amino acids by Na+ flow.
In vitro	ATA3 is a novel subtype of amino acid transport system A, which is mainly presented in liver and skeletal muscle. ATA1(also known as GlnT) and ATA2(also known as SAT2) have been cloned from rat and human tissues. These transporters control the uptake of short chain neutral amino acids in a Na + dependent manner [1] .
Synonyms	α-(Methylamino)isobutyric acid

Chemical Properties

Molecular Weight	117.15
Formula	C₅H₁₁NO₂
Cas No.	2566-34-9
Smiles	CNC(C)(C)C(O)=O
Relative Density.	1.2000 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.0 mg/mL (384.1 mM), when pH is adjusted to 2 with 1M HCl. Sonication and heating to 60℃ are recommended.

H2O: 90.0 mg/mL (768.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (17.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	8.5361 mL	42.6803 mL	85.3606 mL	426.8032 mL
5 mM	1.7072 mL	8.5361 mL	17.0721 mL	85.3606 mL
10 mM	0.8536 mL	4.2680 mL	8.5361 mL	42.6803 mL
20 mM	0.4268 mL	2.1340 mL	4.2680 mL	21.3402 mL
50 mM	0.1707 mL	0.8536 mL	1.7072 mL	8.5361 mL
100 mM	0.0854 mL	0.4268 mL	0.8536 mL	4.2680 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc