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Z-LEHD-fmk

Name: Z-LEHD-fmk
Brand: TargetMol
SKU: T21835
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21835Cas No. 210345-04-3

Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of [Bubalus bubalis], and alters the cellular stress response.

Z-LEHD-fmk

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Purity: 96.13%

Catalog No. T21835Cas No. 210345-04-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$198	In Stock	In Stock
5 mg	$619	In Stock	In Stock
10 mg	$877	-	In Stock
25 mg	$1,280	-	In Stock
50 mg	$1,750	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:96.13%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of [Bubalus bubalis], and alters the cellular stress response.
In vitro	Pretreated for 30 minutes at a concentration of 20 μM, Z-LEHD-FMK completely protects HCT116 and 293 cells from TRAIL-induced toxicity[1]. Additionally, at a concentration of 20 μM for 6 hours, Z-LEHD-FMK protects normal human hepatocytes from TRAIL-induced apoptosis[1].
In vivo	In spinal cord injury (SCI) rats, Z-LEHD-FMK administered intravenously at a dose of 0.8 μmol/kg for 7 days protects neurons, glia, myelin, axons, and intracellular organelles[3].

Chemical Properties

Molecular Weight	690.72
Formula	C₃₂H₄₃FN₆O₁₀
Cas No.	210345-04-3
Smiles	COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
Relative Density.	1.272 g/cm3 (Predicted)
Sequence	Cbz-Leu-Glu(OMe)-His-Asp(OMe)-CH2F
Sequence Short	LXHX

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (130.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4478 mL	7.2388 mL	14.4776 mL	72.3882 mL
5 mM	0.2896 mL	1.4478 mL	2.8955 mL	14.4776 mL
10 mM	0.1448 mL	0.7239 mL	1.4478 mL	7.2388 mL
20 mM	0.0724 mL	0.3619 mL	0.7239 mL	3.6194 mL
50 mM	0.0290 mL	0.1448 mL	0.2896 mL	1.4478 mL
100 mM	0.0145 mL	0.0724 mL	0.1448 mL	0.7239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc