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Anti-IL-8/CXCL8 Antibody (1N881)
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Catalog No. TMAY-03915
Anti-IL-8/CXCL8 Antibody (1N881) is a Rabbit antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (1N881) can be used in ELISA.
Anti-IL-8/CXCL8 Antibody (1N881)
Anti-IL-8/CXCL8 Antibody (1N881)
😃Good
Catalog No. TMAY-03915
Anti-IL-8/CXCL8 Antibody (1N881) is a Rabbit antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (1N881) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Chemical Properties
| Description | Anti-IL-8/CXCL8 Antibody (1N881) is a Rabbit antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (1N881) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1N881 |
| Reactivity | Rhesus |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Rhesus IL-8 / Interleukin-8 / CXCL8 ( TMPY-03480; NP_001028137.1; Ala23-Pro101). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rhesus IL-8 / Interleukin-8 / CXCL8 Protein (TMPY-03480) |
| Antigen Species | Rhesus |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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