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Anti-Polycystin 2 Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11629
Anti-Polycystin 2 Polyclonal Antibody 2 is a Rabbit antibody targeting Polycystin 2. Anti-Polycystin 2 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Anti-Polycystin 2 Polyclonal Antibody 2
Anti-Polycystin 2 Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11629
Anti-Polycystin 2 Polyclonal Antibody 2 is a Rabbit antibody targeting Polycystin 2. Anti-Polycystin 2 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Polycystin 2 Polyclonal Antibody 2 is a Rabbit antibody targeting Polycystin 2. Anti-Polycystin 2 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Chicken,Dog,Cow) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum. Cell projection, cilium. |
| Tissue Specificity | Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]. |
| Immunogen | KLH conjugated synthetic peptide: human Polycystin 2 |
| Antigen Species | Human |
| Gene Name | PKD2 |
| Gene ID | |
| Protein Name | Polycystin-2 |
| Uniprot ID | |
| Function | Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. |
| Molecular Weight | Theoretical: 106 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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