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Anti-CCR6 Antibody (4L318)
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Catalog No. TMAH-00159
Alias STRL22, GPR-CY4, GPRCY4, GPR29, DRY-6, DRY6, DCR2, CMKBR6, CKR-L3, CKRL3, CD196, CCR-6, CC-CKR-6, C-C CKR-6, BN-1
Anti-CCR6 Antibody (4L318) is an antibody targeting CCR6. Anti-CCR6 Antibody (4L318) can be used in ELISA.
Anti-CCR6 Antibody (4L318)
Anti-CCR6 Antibody (4L318)
😃Good
Catalog No. TMAH-00159Alias STRL22, GPR-CY4, GPRCY4, GPR29, DRY-6, DRY6, DCR2, CMKBR6, CKR-L3, CKRL3, CD196, CCR-6, CC-CKR-6, C-C CKR-6, BN-1
Anti-CCR6 Antibody (4L318) is an antibody targeting CCR6. Anti-CCR6 Antibody (4L318) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA Reactivity: Human |
| Alias | STRL22, GPR-CY4, GPRCY4, GPR29, DRY-6, DRY6, DCR2, CMKBR6, CKR-L3, CKRL3, CD196, CCR-6, CC-CKR-6, C-C CKR-6, BN-1 |
| Ig Type | Human IgG1 |
| Clone | 4L318 |
| Reactivity | Human |
| Application | ELISA |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Cell surface. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells. Positively regulates sperm motility and chemotaxis via its binding to CCL20. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CCR6 Protein |
| Antigen Species | Human |
| Gene ID | 1235 |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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