keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 47.00 |
Description | Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness. |
In vitro | The combination of Acetazolamide sodium (0-160 μM) with MS-275 (0.75 μM) exhibited dose-dependent inhibition of growth, induced cell cycle arrest and apoptosis, and reduced migration ability in NB cell line SH-SY5Y[1]. |
In vivo | In preclinical xenograft models, treatment with AZ (40 mg/kg), MS-275 (20 mg/kg), and AZ + MS-275 (40 + 20 mg/kg) for 14 days significantly inhibited tumor growth in vivo. The expression of HIF-1α and CAIX markedly decreased, while apoptosis in NB xenograft cells of SH-SY5Y significantly increased[1]. |
Synonyms | OT-302 sodium |
Molecular Weight | 244.23 |
Formula | C4H5N4NaO3S2 |
CAS No. | 1424-27-7 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 80 mg/mL (4.08 mM), Sonication is recommended.
DMSO: 80 mg/mL (4.08 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Acetazolamide sodium 1424-27-7 Metabolism Carbonic Anhydrase OT-302 sodium inhibitor inhibit