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Acetazolamide sodium

Name: Acetazolamide sodium
Brand: TargetMol
SKU: T60351
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60351Cas No. 1424-27-7

Alias OT-302 sodium

Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness.

Acetazolamide sodium

🥰Excellent

Purity: 99.87%

Catalog No. T60351Alias OT-302 sodiumCas No. 1424-27-7

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness.
In vitro	The combination of Acetazolamide sodium (0-160 μM) with MS-275 (0.75 μM) exhibited dose-dependent inhibition of growth, induced cell cycle arrest and apoptosis, and reduced migration ability in NB cell line SH-SY5Y[1].
In vivo	In preclinical xenograft models, treatment with AZ (40 mg/kg), MS-275 (20 mg/kg), and AZ + MS-275 (40 + 20 mg/kg) for 14 days significantly inhibited tumor growth in vivo. The expression of HIF-1α and CAIX markedly decreased, while apoptosis in NB xenograft cells of SH-SY5Y significantly increased[1].
Synonyms	OT-302 sodium

Chemical Properties

Molecular Weight	244.23
Formula	C₄H₅N₄NaO₃S₂
Cas No.	1424-27-7
Smiles	O=C(C)NC1=NN=C(S(=O)([NH-])=O)S1.[Na+]

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (327.56 mM), Sonication is recommended.

DMSO: 80 mg/mL (327.56 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0945 mL	20.4725 mL	40.9450 mL	204.7251 mL
5 mM	0.8189 mL	4.0945 mL	8.1890 mL	40.9450 mL
10 mM	0.4095 mL	2.0473 mL	4.0945 mL	20.4725 mL
20 mM	0.2047 mL	1.0236 mL	2.0473 mL	10.2363 mL
50 mM	0.0819 mL	0.4095 mL	0.8189 mL	4.0945 mL
100 mM	0.0409 mL	0.2047 mL	0.4095 mL	2.0473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc