Shopping Cart

Your shopping cart is currently empty

Quinoclamine

Name: Quinoclamine
Brand: TargetMol
SKU: T16706
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16706Cas No. 2797-51-5

Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.

Quinoclamine

🥰Excellent

Purity: 99.28%

Catalog No. T16706Cas No. 2797-51-5

Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$40	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$155	In Stock	In Stock
1 g	$228	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.28%

Appearance:Solid

Color:orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.

In vitro

Quinoclamine induces the differentiation of U-937 cells into macrophage-like cells. Quinoclamine inhibits NF-κB activities in HepG2 cells (IC50: 1.7 μM). Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines. Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis. Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism. Quinoclamine (1-4 μM; 30 minutes ) inhibits endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation [1][2].

Chemical Properties

Molecular Weight	207.61
Formula	C₁₀H₆ClNO₂
Cas No.	2797-51-5
Smiles	NC1=C(Cl)C(=O)C2=C(C=CC=C2)C1=O
Relative Density.	1.49 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (240.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8167 mL	24.0836 mL	48.1672 mL	240.8362 mL
5 mM	0.9633 mL	4.8167 mL	9.6334 mL	48.1672 mL
10 mM	0.4817 mL	2.4084 mL	4.8167 mL	24.0836 mL
20 mM	0.2408 mL	1.2042 mL	2.4084 mL	12.0418 mL
50 mM	0.0963 mL	0.4817 mL	0.9633 mL	4.8167 mL
100 mM	0.0482 mL	0.2408 mL	0.4817 mL	2.4084 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc