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Anti-HIF1A Polyclonal Antibody
😃Good
Catalog No. TMAB-07030
Anti-HIF1A Polyclonal Antibody is a Rabbit antibody targeting HIF1A. Anti-HIF1A Polyclonal Antibody can be used in ICC/IF.
Anti-HIF1A Polyclonal Antibody
Anti-HIF1A Polyclonal Antibody
😃Good
Catalog No. TMAB-07030
Anti-HIF1A Polyclonal Antibody is a Rabbit antibody targeting HIF1A. Anti-HIF1A Polyclonal Antibody can be used in ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HIF1A Polyclonal Antibody is a Rabbit antibody targeting HIF1A. Anti-HIF1A Polyclonal Antibody can be used in ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | ICC/IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Tissue Specificity | Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Hypoxia-inducible factor 1-alpha (HIF-1α) plays a particularly crucial role in maintaining normal physiological functions under hypoxic conditions and is also significantly involved in pathological processes such as tumor growth and neuronal apoptosis. HIF-1α regulates the expression levels of numerous downstream genes. In mammalian cells, HIF is induced under hypoxic stress conditions. As a transcription factor, HIF stabilizes cells in response to hypoxia. |
| Immunogen | Recombinant Protein: human HIF-1 Alpha protein |
| Antigen Species | Human |
| Gene Name | HIF1A |
| Gene ID | |
| Protein Name | Hypoxia-inducible factor 1-alpha |
| Uniprot ID | |
| Function | Functions as a master transcriptional regulator of theadaptive response to hypoxia. Under hypoxic conditions activatesthe transcription of over 40 genes, including, erythropoietin,glucose transporters, glycolytic enzymes, vascular endothelialgrowth factor, and other genes whose protein products increaseoxygen delivery or facilitate metabolic adaptation to hypoxia.Plays an essential role in embryonic vascularization, tumorangiogenesis and pathophysiology of ischemic disease. Binds to coreDNA sequence 5'-[AG]CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment oftranscriptional coactivators such as CREBPB and EP300. Activity isenhanced by interaction with both, NCOA1 or NCOA2. Interaction withredox regulatory protein APEX seems to activate CTAD andpotentiates activation by NCOA1 and CREBBP. |
| Molecular Weight | Theoretical: 92 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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