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Jarin-1

Name: Jarin-1
Brand: TargetMol
SKU: T15608
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15608Cas No. 1212704-51-2

Jarin-1, a jasmonic acid-amido synthetase (JAR1) inhibitor (IC50: 3.8 μM), specifically suppresses bioactive JA biosynthesis in Arabidopsis and other plants.

Jarin-1

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Purity: 99.82%

Catalog No. T15608Cas No. 1212704-51-2

Jarin-1, a jasmonic acid-amido synthetase (JAR1) inhibitor (IC50: 3.8 μM), specifically suppresses bioactive JA biosynthesis in Arabidopsis and other plants.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$72	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$558	In Stock	In Stock
50 mg	$788	In Stock	In Stock
100 mg	$1,120	-	In Stock
1 mL x 10 mM (in DMSO)	$213	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

Jarin-1, a jasmonic acid-amido synthetase (JAR1) inhibitor (IC50: 3.8 μM), specifically suppresses bioactive JA biosynthesis in Arabidopsis and other plants.

In vitro

MeJA + Jarin-1 treatment caused an upregulation of FaANR and associated transcription factors such as FabHLH33 and FaMYB9/11 along with FaJMT and FaJAR1.2. JA-responsive elements in the promoter regions of FaMYB1/9/10/11 genes are found. The proanthocyanidin (PA) content was higher in Jarin-1- and MeJA + Jarin-1-treated than in MeJA-treated fruits. PA biosynthesis-related genes can be upregulated by the application of Jarin-1 to MeJA-treated fruit, thus increasing PA accumulation in strawberry. A higher redness of strawberry fruit skin and anthocyanin content in MeJA-treated fruits with respect to Jarin-1-treated ones concomitant with an upregulation of FaANS and FaUFGT genes is found [1].

Chemical Properties

Molecular Weight	471.55
Formula	C₂₈H₂₉N₃O₄
Cas No.	1212704-51-2
Smiles	[H][C@@]12CN(C[C@@]([H])(C1)c1ccc(NC(=O)c3ccc(cc3)-c3ccccc3)c(=O)n1C2)C(=O)CCOC
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (318.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1207 mL	10.6033 mL	21.2067 mL	106.0333 mL
5 mM	0.4241 mL	2.1207 mL	4.2413 mL	21.2067 mL
10 mM	0.2121 mL	1.0603 mL	2.1207 mL	10.6033 mL
20 mM	0.1060 mL	0.5302 mL	1.0603 mL	5.3017 mL
50 mM	0.0424 mL	0.2121 mL	0.4241 mL	2.1207 mL
100 mM	0.0212 mL	0.1060 mL	0.2121 mL	1.0603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc