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Zenarestat

Name: Zenarestat
Brand: TargetMol
SKU: T35299
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35299Cas No. 112733-06-9

Alias FR-74366, FR74366, FR 74366, CI-1014, CI1014

Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.

Zenarestat

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Purity: 99.51%

Catalog No. T35299Alias FR-74366, FR74366, FR 74366, CI-1014, CI1014Cas No. 112733-06-9

Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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Purity:99.51%

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Product Introduction

Bioactivity

Description	Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.
In vivo	Methods: Zenarestat (3.2 mg/kg and 32 mg/kg, once daily for 8 consecutive weeks) was orally administered to Zucker diabetic fatty (ZDF) rats to investigate the effects of zenarestat on peripheral neuropathy in the type 2 diabetes animal model ZDF rats. Results: At the dose of 3.2 mg/kg, zenarestat did not show significant effects on FML latency delay and MNCV slowing; however, at the dose of 32 mg/kg, zenarestat treatment significantly improved these neurologic disorders in ZDF rats and reduced the accumulation of sorbitol in nerves to levels nearly equivalent to those in lean rats.[3]
Synonyms	FR-74366, FR74366, FR 74366, CI-1014, CI1014

Chemical Properties

Molecular Weight	441.64
Formula	C₁₇H₁₁BrClFN₂O₄
Cas No.	112733-06-9
Smiles	O=C(O)CN1C(=O)N(C(=O)C2=CC=C(Cl)C=C21)CC3=CC=C(Br)C=C3F
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (181.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2643 mL	11.3214 mL	22.6429 mL	113.2144 mL
5 mM	0.4529 mL	2.2643 mL	4.5286 mL	22.6429 mL
10 mM	0.2264 mL	1.1321 mL	2.2643 mL	11.3214 mL
20 mM	0.1132 mL	0.5661 mL	1.1321 mL	5.6607 mL
50 mM	0.0453 mL	0.2264 mL	0.4529 mL	2.2643 mL
100 mM	0.0226 mL	0.1132 mL	0.2264 mL	1.1321 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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