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Zenarestat

Name: Zenarestat
Brand: TargetMol
SKU: T35299
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35299Cas No. 112733-06-9

Alias FR-74366, FR74366, FR 74366, CI-1014, CI1014

Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.

Zenarestat

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Purity: 99.51%

Catalog No. T35299Alias FR-74366, FR74366, FR 74366, CI-1014, CI1014Cas No. 112733-06-9

Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.
In vivo	Methods: Zenarestat (3.2 mg/kg and 32 mg/kg, once daily for 8 consecutive weeks) was orally administered to Zucker diabetic fatty (ZDF) rats to investigate the effects of zenarestat on peripheral neuropathy in the type 2 diabetes animal model ZDF rats. Results: At the dose of 3.2 mg/kg, zenarestat did not show significant effects on FML latency delay and MNCV slowing; however, at the dose of 32 mg/kg, zenarestat treatment significantly improved these neurologic disorders in ZDF rats and reduced the accumulation of sorbitol in nerves to levels nearly equivalent to those in lean rats.[3]
Synonyms	FR-74366, FR74366, FR 74366, CI-1014, CI1014

Chemical Properties

Molecular Weight	441.64
Formula	C₁₇H₁₁BrClFN₂O₄
Cas No.	112733-06-9
Smiles	O=C(O)CN1C(=O)N(C(=O)C2=CC=C(Cl)C=C21)CC3=CC=C(Br)C=C3F
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (181.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2643 mL	11.3214 mL	22.6429 mL	113.2144 mL
5 mM	0.4529 mL	2.2643 mL	4.5286 mL	22.6429 mL
10 mM	0.2264 mL	1.1321 mL	2.2643 mL	11.3214 mL
20 mM	0.1132 mL	0.5661 mL	1.1321 mL	5.6607 mL
50 mM	0.0453 mL	0.2264 mL	0.4529 mL	2.2643 mL
100 mM	0.0226 mL	0.1132 mL	0.2264 mL	1.1321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc