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Olorinab

Name: Olorinab
Brand: TargetMol
SKU: T14302
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14302Cas No. 1268881-20-4

Alias APD 371

Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.

Olorinab

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Purity: 98.47%

Catalog No. T14302Alias APD 371Cas No. 1268881-20-4

Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$397	In Stock
50 mg	$589	In Stock

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Purity:98.47%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
Targets&IC50	CB2 (human):（EC50）6.2 nM
In vitro	A comprehensive in vitro profile of Olorinab (APD 371) (6) demonstrates single-digit nanomolar potency and full intrinsic efficacy across all species assessed. It is highly selective for CB2 over CB1 in both binding and functional assays and induces efficient receptor internalization (~106% relative to the CB1/2 agonist CP55,940) in CHO cells expressing HA-tagged rat CB2, suggesting it can drive agonist-induced receptor recycling[1].
In vivo	Olorinab (APD 371) significantly increases paw withdrawal thresholds at doses ≥3 mg/kg PO (ED50=2.3 mg/kg), with its analgesic effects likely mediated via activity at CB2 receptors[1]. A single dose of Olorinab (APD 371) (10 mg/kg, PO) inhibits paw withdrawal threshold for up to 4 hours after administration.
Synonyms	APD 371

Chemical Properties

Molecular Weight	357.41
Formula	C₁₈H₂₃N₅O₃
Cas No.	1268881-20-4
Smiles	CC(C)(C)[C@@H](CO)NC(C1=NN(C2=NC=C[N+]([O-])=C2)C3=C1C[C@@]4([H])[C@]3([H])C4)=O
Relative Density.	1.49 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (503.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7979 mL	13.9895 mL	27.9791 mL	139.8954 mL
5 mM	0.5596 mL	2.7979 mL	5.5958 mL	27.9791 mL
10 mM	0.2798 mL	1.3990 mL	2.7979 mL	13.9895 mL
20 mM	0.1399 mL	0.6995 mL	1.3990 mL	6.9948 mL
50 mM	0.0560 mL	0.2798 mL	0.5596 mL	2.7979 mL
100 mM	0.0280 mL	0.1399 mL	0.2798 mL	1.3990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc