Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a substantial increase in differentially expressed genes and augmented apoptosis in HCT116 cells [1].
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Description | JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a substantial increase in differentially expressed genes and augmented apoptosis in HCT116 cells [1]. |
Molecular Weight | 1012.14 |
Formula | C50H64F3N7O10S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JPS016 TFA Chromatin/Epigenetic DNA Damage/DNA Repair HDAC inhibitor inhibit