Shopping Cart

Your shopping cart is currently empty

NOT Receptor Modulator 1 (Alias: 2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol)

Name: NOT Receptor Modulator 1
Brand: TargetMol
SKU: T12247
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12247 Copy Product Info

Purity: 99.87%

😃Good

NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) is a modulator of nuclear receptor NOT.

NOT Receptor Modulator 1

Copy Product Info

😃Good

Catalog No. T12247

Alias 2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol

NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) is a modulator of nuclear receptor NOT.

Cas No. 1015231-98-7

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
1 mg	$30	In Stock	In Stock
5 mg	$71	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$202	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$389	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS HPLC

Product Introduction

NOT Receptor Modulator 1 AI Summary

NOT Receptor Modulator 1 shows a variety of bioactivities. It exhibits agonist activity at Nurr1 in mouse MG7 cells by inhibiting LPS-induced neurotoxicity and IL1beta secretion, and by increasing tyrosine hydroxylase expression in rat mesencephalic primary neurons. Additionally, it shows agonist activity in a luciferase reporter gene assay and inhibits human ERG. The compound also demonstrates anti-inflammatory activity by inhibiting LPS-induced TNFalpha release in Sprague-Dawley rats..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) is a modulator of nuclear receptor NOT.
Synonyms	2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol

Chemical Properties

Molecular Weight	362.85
Formula	C₂₂H₁₉ClN₂O
Cas No.	1015231-98-7
Smiles	CC(C)(O)c1cccc(c1)-c1ccc2nc(cn2c1)-c1ccc(Cl)cc1
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (165.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7560 mL	13.7798 mL	27.5596 mL	137.7980 mL
5 mM	0.5512 mL	2.7560 mL	5.5119 mL	27.5596 mL
10 mM	0.2756 mL	1.3780 mL	2.7560 mL	13.7798 mL
20 mM	0.1378 mL	0.6890 mL	1.3780 mL	6.8899 mL
50 mM	0.0551 mL	0.2756 mL	0.5512 mL	2.7560 mL
100 mM	0.0276 mL	0.1378 mL	0.2756 mL	1.3780 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc