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ZINC69391
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Catalog No. T24833Cas No. 303094-67-9
Alias ZINC-69391, ZINC 69391, N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine, CysHHC10 acetate(1408311-03-4 free base)
ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
ZINC69391
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Purity: 99.61%
Catalog No. T24833Alias ZINC-69391, ZINC 69391, N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine, CysHHC10 acetate(1408311-03-4 free base)Cas No. 303094-67-9
ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $31 | In Stock | In Stock | |
| 5 mg | $75 | In Stock | In Stock | |
| 10 mg | $121 | In Stock | In Stock | |
| 25 mg | $219 | In Stock | In Stock | |
| 50 mg | $306 | In Stock | In Stock | |
| 100 mg | $413 | In Stock | In Stock | |
| 200 mg | $548 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $83 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.61%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis. |
| In vitro | In U-87 MG and LN229 cells, ZINC69391 (0-125 μM) reduces cell proliferation of human glioma cells. ZINC69391 (50-100 μM) triggers cell cycle arrest[1]. ZINC69391 inhibits the growth of U937, HL-60, KG1A, and Jurkat cells (IC50s = 41-54 μM). In HL-60, U937, and KG1A cell lines, ZINC69391 (50 μM) triggers an increase in apoptotic cells. In LN229 cells, ZINC69391 (50 and 100 μM) augments the enzymatic activity of caspase 3 and increases the percentage of cells in the sub-G0/G1 phase in a concentration-dependent manner[3]. |
| In vivo | In specific pathogen-free female BALB/c inbred mice (bearing F3II cells), ZINC69391 (25 mg/kg; i.p) impairs metastatic lung colonization and reduces by about 60% the formation of total metastatic lung colonies[2]. |
| Synonyms | ZINC-69391, ZINC 69391, N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine, CysHHC10 acetate(1408311-03-4 free base) |
| Molecular Weight | 309.29 |
| Formula | C14H14F3N5 |
| Cas No. | 303094-67-9 |
| Smiles | Cc1cc(C)nc(NC(=N)Nc2ccccc2C(F)(F)F)n1 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (64.66 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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