Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

AM-2099

Name: AM-2099
Brand: TargetMol
SKU: T14201
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T14201Cas No. 1443373-17-8

Alias AM2099

AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.

AM-2099

😃Good

Catalog No. T14201Alias AM2099Cas No. 1443373-17-8

AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$299	5 days	5 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.
Targets&IC50	Nav1.7 (rat):3.5 μM, Nav1.7 (human):0.16 μM, Nav1.7 (mouse):0.18 μM
In vitro	AM-2099 is more than 100-fold selective over Nav1.3, Nav1.4, Nav1.5, and Nav1.8, while lower levels of selectivity are observed against Nav1.1, Nav1.2, and Nav1.6. AM-2099 demonstrates low affinity for hERG (>30 µM) and does not show greater than 50% inhibition against a panel of 100 kinases (1 µM) and a broad CEREP panel (10 µM). In heterologous cells, comparable inhibition is observed across human, mouse, dog, and cynomolgus monkey NaV1.7 with reduced activity against rat NaV1.7.[1]
In vivo	AM-2099 demonstrates a dose-dependent increase in plasma exposure with a concomitant dose-dependent reduction in scratching bouts compared to vehicle-treated animals, with a statistically significant reduction observed at the 60 mg/kg dose. AM-2099 demonstrates a favorable pharmacokinetic profile in rat and dog. In rats AM-2099 shows low total clearance and moderate Vdss and half-life. However, when dosed in dogs AM-2099 shows very low clearance, a low Vdss and long halflife (18 h).[1]
Synonyms	AM2099

Chemical Properties

Molecular Weight	466.46
Formula	C₁₉H₁₃F₃N₄O₃S₂
Cas No.	1443373-17-8
Smiles	O=S(=O)(NC1=NC=CS1)C=2C=CC=3C(=NC=NC3C=4C=CC(=CC4OC)C(F)(F)F)C2
Relative Density.	1.531 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (257.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1438 mL	10.7190 mL	21.4381 mL	107.1903 mL
5 mM	0.4288 mL	2.1438 mL	4.2876 mL	21.4381 mL
10 mM	0.2144 mL	1.0719 mL	2.1438 mL	10.7190 mL
20 mM	0.1072 mL	0.5360 mL	1.0719 mL	5.3595 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	2.1438 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0719 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc