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U3-1565
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Catalog No. T77438
Alias U31565, Anti-HB-EGF antibody
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.
U3-1565
U3-1565
😃Good
Catalog No. T77438Alias U31565, Anti-HB-EGF antibody
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $447 | - | In Stock | |
| 5 mg | $1,400 | - | In Stock | |
| 10 mg | $2,240 | - | In Stock | |
| 25 mg | $4,210 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:>95.0% (SDS-PAGE); 99.8% (SEC-HPLC)
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| Description | U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors. |
| In vitro | Inhibition of basal pEGFR levels by U3-1565 was demonstrated in various cancer cell lines. U3-1565 inhibits EGFR activation in vitro and reduces angiogenesis in vivo. U3-1565 showed dose-dependent inhibition of HB-EGF-stimulated pHER4 and pERK activation in vitro. [1] |
| In vivo | In HB-EGF overexpressed ovarian cancer xenotransplantation model, U3-1565 as a single drug showed tumor cell growth inhibition in vivo. Xenograft model studies have shown that the antitumor activity of U3-1565 is based on inhibition of EGFR activation and prevention of carcinogenic MAPK signaling. [1] |
| Synonyms | U31565, Anti-HB-EGF antibody |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | HBEGF |
| Molecular Weight | 144.82 kDa. |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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