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U3-1565 (Synonyms: U31565, Anti-HB-EGF antibody)

Catalog No. T77438 Copy Product Info
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U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.

U3-1565

Copy Product Info
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Catalog No. T77438
Synonyms U31565, Anti-HB-EGF antibody

U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.

U3-1565
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$447-In Stock
5 mg$1,400-In Stock
10 mg$2,240-In Stock
25 mg$4,210-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:>95.0% (SDS-PAGE); 99.8% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.
In vitro
Inhibition of basal pEGFR levels by U3-1565 was demonstrated in various cancer cell lines. U3-1565 inhibits EGFR activation in vitro and reduces angiogenesis in vivo. U3-1565 showed dose-dependent inhibition of HB-EGF-stimulated pHER4 and pERK activation in vitro. [1]
In vivo
In HB-EGF overexpressed ovarian cancer xenotransplantation model, U3-1565 as a single drug showed tumor cell growth inhibition in vivo. Xenograft model studies have shown that the antitumor activity of U3-1565 is based on inhibition of EGFR activation and prevention of carcinogenic MAPK signaling. [1]
SynonymsU31565, Anti-HB-EGF antibody
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetHBEGF
Chemical Properties
Molecular Weight144.82 kDa.
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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