Shopping Cart

Your shopping cart is currently empty

AH 6809

Name: AH 6809
Brand: TargetMol
SKU: T14148
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T14148Cas No. 33458-93-4

AH 6809 is an antagonist of EP and DP receptors, with Ki values of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptors, respectively, and a Ki of 350 nM for the mouse EP2 receptor.

AH 6809

Copy Product Info

😃Good

Purity: 97.59%

Catalog No. T14148Cas No. 33458-93-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$61	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$177	In Stock	In Stock
50 mg	$278	In Stock	In Stock
100 mg	$446	In Stock	In Stock
200 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.59%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

AH 6809 AI Summary

AH 6809 exhibits a diverse range of bioactivities, including potent inhibition of several key targets and receptors. It demonstrates significant inhibitory effects on Menin-MLL interaction in MLL-related leukemias, with potencies ranging from 12589.3 nM to 39810.7 nM. It is a potent inhibitor of Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 0.8 nM and shows inhibitory activities against HSD17B4, JMJD2E, ALDH1A1, HPGD, and USP1/UAF1, with potencies ranging between 12589.3 nM and 39810.7 nM. Additionally, AH 6809 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM with an inhibition rate of 12.65% but shows less significant activity in VERO-6 cells under the same conditions. It also inhibits SARS-CoV-2 3CL-Pro protease by 3.982% at 20 µM. The compound is an antagonist at EP2, EP1, EP3, and DP1 receptors, with highest potency at EP2. Moreover, it shows potential as an HDAC6 inhibitor, with inhibition percentages of 87.42% using a commercial substrate and 76.3% with a custom substrate. AH 6809's bioactivity portfolio spans antiviral, epigenetic, and cancer-related pathways, indicating its broad therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AH 6809 is an antagonist of EP and DP receptors, with Ki values of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptors, respectively, and a Ki of 350 nM for the mouse EP2 receptor.
Targets&IC50	EP1:1217 nM (Ki)(human), EP3:1597 nM (Ki)(human), EP2:1150 nM (Ki)(human), EP2:350 nM (Ki)(mouse), DP:1415 nM (Ki)(human)

Chemical Properties

Molecular Weight	298.29
Formula	C₁₇H₁₄O₅
Cas No.	33458-93-4
Smiles	CC(C)Oc1ccc2c(c1)oc1ccc(cc1c2=O)C(O)=O
Relative Density.	1.334g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (83.81 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3524 mL	16.7622 mL	33.5244 mL	167.6221 mL
5 mM	0.6705 mL	3.3524 mL	6.7049 mL	33.5244 mL
10 mM	0.3352 mL	1.6762 mL	3.3524 mL	16.7622 mL
20 mM	0.1676 mL	0.8381 mL	1.6762 mL	8.3811 mL
50 mM	0.0670 mL	0.3352 mL	0.6705 mL	3.3524 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc