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Cephaeline dihydrochloride

🥰Excellent
Catalog No. TQ0109Cas No. 5853-29-2
Alias NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride

Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.

Cephaeline dihydrochloride

Cephaeline dihydrochloride

🥰Excellent
Purity: 99.67%
Catalog No. TQ0109Alias NSC32944, NSC 32944, (-)-Cephaeline dihydrochlorideCas No. 5853-29-2
Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
Pack SizePriceAvailabilityQuantity
2 mg$71In Stock
5 mg$98In Stock
10 mg$148In Stock
25 mg$298In Stock
50 mg$481In Stock
1 mL x 10 mM (in DMSO)$117In Stock
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Purity:99.67%
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Product Introduction

Bioactivity
Description
Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
Targets&IC50
CYP2D6:121 μM, CYP3A4:1000 μM
In vitro
In human liver microsome assays, Cephaeline dihydrochloride demonstrated weak inhibition of major cytochrome P450 (CYP) enzymes. Specifically, Cephaeline dihydrochloride inhibited CYP2D6 with an IC₅₀ of 121 μM and a Ki of 54 μM via competitive inhibition, and CYP3A4 with an IC₅₀ of 1000 μM and a Ki of 355 μM via non-competitive inhibition[1].
AliasNSC32944, NSC 32944, (-)-Cephaeline dihydrochloride
Chemical Properties
Molecular Weight539.53
FormulaC28H40Cl2N2O4
Cas No.5853-29-2
SmilesCOC(C=C(CCN1C[C@@H]2CC)C([C@]1([H])C[C@@H]2C[C@@H]3C4=CC(OC)=C(O)C=C4CCN3)=C5)=C5OC.Cl.Cl
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200.00 mg/mL (370.69 mM), Sonication is recommended.
H2O: 100.00 mg/mL (185.35 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.8535 mL9.2673 mL18.5347 mL92.6733 mL
5 mM0.3707 mL1.8535 mL3.7069 mL18.5347 mL
10 mM0.1853 mL0.9267 mL1.8535 mL9.2673 mL
20 mM0.0927 mL0.4634 mL0.9267 mL4.6337 mL
50 mM0.0371 mL0.1853 mL0.3707 mL1.8535 mL
100 mM0.0185 mL0.0927 mL0.1853 mL0.9267 mL

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