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Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $71 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $148 | In Stock | |
25 mg | $298 | In Stock | |
50 mg | $481 | In Stock | |
1 mL x 10 mM (in DMSO) | $117 | In Stock |
Description | Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting. |
Targets&IC50 | CYP2D6:121 μM, CYP3A4:1000 μM |
In vitro | In human liver microsome assays, Cephaeline dihydrochloride demonstrated weak inhibition of major cytochrome P450 (CYP) enzymes. Specifically, Cephaeline dihydrochloride inhibited CYP2D6 with an IC₅₀ of 121 μM and a Ki of 54 μM via competitive inhibition, and CYP3A4 with an IC₅₀ of 1000 μM and a Ki of 355 μM via non-competitive inhibition[1]. |
Alias | NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride |
Molecular Weight | 539.53 |
Formula | C28H40Cl2N2O4 |
Cas No. | 5853-29-2 |
Smiles | COC(C=C(CCN1C[C@@H]2CC)C([C@]1([H])C[C@@H]2C[C@@H]3C4=CC(OC)=C(O)C=C4CCN3)=C5)=C5OC.Cl.Cl |
Relative Density. | 1.31g/cm3 |
Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200.00 mg/mL (370.69 mM), Sonication is recommended. H2O: 100.00 mg/mL (185.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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