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Cephaeline dihydrochloride
🥰Excellent
Catalog No. TQ0109Cas No. 5853-29-2
Alias NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride
Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
Cephaeline dihydrochloride
🥰Excellent
Purity: 99.67%
Catalog No. TQ0109Alias NSC32944, NSC 32944, (-)-Cephaeline dihydrochlorideCas No. 5853-29-2
Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $71 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $148 | In Stock | |
| 25 mg | $298 | In Stock | |
| 50 mg | $481 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | In Stock |
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Purity:99.67%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting. |
| Targets&IC50 | CYP3A4:1000 μM, CYP2D6:121 μM |
| In vitro | In human liver microsome assays, Cephaeline dihydrochloride demonstrated weak inhibition of major cytochrome P450 (CYP) enzymes. Specifically, Cephaeline dihydrochloride inhibited CYP2D6 with an IC₅₀ of 121 μM and a Ki of 54 μM via competitive inhibition, and CYP3A4 with an IC₅₀ of 1000 μM and a Ki of 355 μM via non-competitive inhibition[1]. |
| Alias | NSC32944, NSC 32944, (-)-Cephaeline dihydrochloride |
| Molecular Weight | 539.53 |
| Formula | C28H40Cl2N2O4 |
| Cas No. | 5853-29-2 |
| Smiles | COC(C=C(CCN1C[C@@H]2CC)C([C@]1([H])C[C@@H]2C[C@@H]3C4=CC(OC)=C(O)C=C4CCN3)=C5)=C5OC.Cl.Cl |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200.00 mg/mL (370.69 mM), Sonication is recommended. H2O: 100.00 mg/mL (185.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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