CDK4/6-IN-3

Name: CDK4/6-IN-3
Brand: TargetMol
SKU: T10737
Rating: 4.5 (1 reviews)

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Catalog No. T10737Cas No. 2366237-37-6

CDK4/6-IN-3, a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM), is used for the treatment of glioblastoma and inhibits CDK1 with a Ki of 110 nM.

CDK4/6-IN-3

😃Good

Catalog No. T10737Cas No. 2366237-37-6

CDK4/6-IN-3, a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM), is used for the treatment of glioblastoma and inhibits CDK1 with a Ki of 110 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$4,020	3-6 months	3-6 months
50 mg	$5,080	3-6 months	3-6 months
100 mg	$6,800	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	CDK4/6-IN-3, a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM), is used for the treatment of glioblastoma and inhibits CDK1 with a Ki of 110 nM.
Targets&IC50	CDK6:2.2 nM (ki), CDK1:110 nM (ki), CDK4:0.3 nM (ki)
In vitro	CDK4/6-IN-3 inhibits MCF7 and BT549 cell lines proliferation (EC50s: 30 nM and 2.1 μM).

Chemical Properties

Molecular Weight	462.57
Formula	C₂₅H₃₁FN₈
Cas No.	2366237-37-6
Smiles	C(C)N1CC2(CN(C2)C=3C=CC(NC=4N=C(C(F)=CN4)C5=C6N(N=C5)CCCC[C@H]6C)=NC3)C1
Relative Density.	1.41 g/cm3 (Predicted)

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Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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