BTM-1086

Name: BTM-1086
Brand: TargetMol
SKU: T10008
Rating: 4.5 (1 reviews)

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Catalog No. T10008Cas No. 72293-17-5

BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent.

BTM-1086

😃Good

Catalog No. T10008Cas No. 72293-17-5

BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	3-6 months	3-6 months
50 mg	$1,980	3-6 months	3-6 months
100 mg	$2,500	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent.
In vitro	BTM-1086 has a high affinity (pKi: 8.31-9.15) for the three muscarinic receptor subtypes in the guinea-pig cortex (M1), heart (M2), and salivary glands (M3) [1].
In vivo	BTM-1086 (0.1 to 1 mg/kg, p.o.) prevents the development of ulcers, but only weakly inhibits the histamine-induced gastric ulcer. The inhibitory activities of BTM-1086 are significantly higher than those of atropine sulfate. In the healing experiment with the acetic acid-induced stomach ulcer, BTM-1086 (1 mg/kg/day, p.o., x14) shows a significant healing effect, which is higher than that of propantheline bromide. BTM-1086 (0.2 mg/kg, i.d.) remarkably inhibit the gastric secretion 6 hr after pylorus ligation. The aspirin-induced reductions of the total acid and K+ as well as the increments of the volume and Na+ in the gastric secretion are prevented dose-dependently by pretreatment with BTM-1086. The LD50 value by oral, s.c., and i.v. administration with BTM-1086 is 880, 630, and 113 mg/kg, respectively, for male rats and 830, 650, and 119 mg/kg, respectively, for female rats [2].

Chemical Properties

Molecular Weight	367.51
Formula	C₂₁H₂₅N₃OS
Cas No.	72293-17-5
Smiles	C([C@@H]1[C@@H](SC=2C(NC1=O)=CC=CC2)C3=CC=CC=C3)N4CCN(C)CC4
Relative Density.	1.176 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc