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Anti-CXCL10 Antibody (8I302)
Catalog No. TMAH-00320 Copy Product Info
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Anti-CXCL10 Antibody (8I302) is an antibody targeting CXCL10. Anti-CXCL10 Antibody (8I302) can be used in ELISA,IHC.
Anti-CXCL10 Antibody (8I302)
Copy Product Info🥰Excellent
Catalog No. TMAH-00320
Anti-CXCL10 Antibody (8I302) is an antibody targeting CXCL10. Anti-CXCL10 Antibody (8I302) can be used in ELISA,IHC.
Anti-CXCL10 Antibody
(8I302)
(8I302)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CXCL10 Antibody (8I302) is an antibody targeting CXCL10. Anti-CXCL10 Antibody (8I302) can be used in ELISA,IHC. |
| Ig Type | Rabbit IgG |
| Clone | 8I302 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00320 diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus. Microglial cells produce CXCL10 in response to viral stimulation. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human IP10 |
| Antigen Species | Human |
| Gene Name | CXCL10 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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