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Selinexor HCl

Name: Selinexor HCl
Brand: TargetMol
SKU: T28747
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Selinexor hydrochloride, Selinexor HCl (1393477-72-9 free base), KPT-330 hydrochloride, KPT330 hydrochloride) Copy Product Info

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Synonyms: Selinexor hydrochloride, Selinexor HCl (1393477-72-9 free base), KPT-330 hydrochloride, KPT330 hydrochloride

Catalog No. T28747 Copy Product Info

Purity: 99.90%

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Selinexor HCl (1393477-72-9 free base) is an oral selective XPO1 (XPO1/CRM1) inhibitor that induces cell cycle arrest and apoptosis in tumor cells by blocking the transport of tumor suppressor proteins from the nucleus to the cytoplasm, thereby promoting their accumulation within the nucleus. Selinexor has been studied for the treatment of malignant tumors such as multiple myeloma.

Pack Size	Price	USA Stock	Global Stock
1 mg	$38	-	In Stock
5 mg	$75	-	In Stock
10 mg	$129	-	In Stock
25 mg	$298	-	In Stock
50 mg	$448	-	In Stock
100 mg	$581	-	In Stock
1 mL x 10 mM (in DMSO)	$82	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.90%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Selinexor HCl (1393477-72-9 free base) is an oral selective XPO1 (XPO1/CRM1) inhibitor that induces cell cycle arrest and apoptosis in tumor cells by blocking the transport of tumor suppressor proteins from the nucleus to the cytoplasm, thereby promoting their accumulation within the nucleus. Selinexor has been studied for the treatment of malignant tumors such as multiple myeloma.
Targets & IC50	KOPTK-1 cells:34 nM, MOLT-4 cells:34 nM, NSCLC:25 nM, HPBALL:34 nM, HEK293T cells:0.73 μM, Jurkat cells:34 nM, HeLa cells:0.43 μM
Synonyms	Selinexor hydrochloride, Selinexor HCl (1393477-72-9 free base), KPT-330 hydrochloride, KPT330 hydrochloride

Chemical Properties

Molecular Weight	479.77
Formula	C₁₇H₁₂ClF₆N₇O
Smiles	O=C(/C=C\N1N=C(N=C1)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)NNC3=NC=CN=C3.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (166.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0843 mL	10.4217 mL	20.8433 mL	104.2166 mL
5 mM	0.4169 mL	2.0843 mL	4.1687 mL	20.8433 mL
10 mM	0.2084 mL	1.0422 mL	2.0843 mL	10.4217 mL
20 mM	0.1042 mL	0.5211 mL	1.0422 mL	5.2108 mL
50 mM	0.0417 mL	0.2084 mL	0.4169 mL	2.0843 mL
100 mM	0.0208 mL	0.1042 mL	0.2084 mL	1.0422 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Selinexor HCl chemical structure | Selinexor HCl formula | Selinexor HCl molecular weight