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NQDI-1
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Catalog No. T3101Cas No. 175026-96-7
Alias NQDI1, NQDI 1
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
NQDI-1
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Purity: 98.80%
Catalog No. T3101Alias NQDI1, NQDI 1Cas No. 175026-96-7
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $67 | In Stock | In Stock | |
| 25 mg | $147 | In Stock | In Stock | |
| 50 mg | $273 | In Stock | In Stock | |
| 100 mg | $413 | - | In Stock | |
| 200 mg | $589 | - | In Stock | |
| 500 mg | $939 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.80%
Appearance:Solid
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Product Introduction
NQDI-1 AI Summary
NQDI-1 demonstrates diverse bioactivities across multiple targets, suggesting its potential as a multi-target therapeutic agent. It exhibits potency in modulating lipid storage, inhibiting histone lysine methyltransferase G9a, delaying death in the malarial parasite plastid, inhibiting Polymerase Iota and Eta, acting as an inverse agonist of the GLP-1 receptor, and inhibiting Pin1. Furthermore, it competitively inhibits human ASK1 with a Ki value of 500 nM and an IC50 value of 3000 nM, and completely inhibits ROCK1 and JNK3 activity at 25 µM after 20 minutes. The compound also shows varying degrees of inhibition against Aurora A, HGFR, FGFR1, Tie2, and CK2. Additionally, NQDI-1 exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells and SARS-CoV-2 3CL-Pro protease by 13.05% at 20 µM. The compound also demonstrates inhibition of human HDAC6 enzyme activity with 41.78% inhibition using a standard peptide substrate. These multifaceted pharmacological effects make NQDI-1 a candidate for further drug development exploration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM). |
| Targets&IC50 | ASK1:500 nM (Ki), ASK1:3 μM, MAP3K5:3 μM |
| Synonyms | NQDI1, NQDI 1 |
| Molecular Weight | 319.31 |
| Formula | C19H13NO4 |
| Cas No. | 175026-96-7 |
| Smiles | CCOC(=O)c1c2-c3ccccc3C(=O)c3cccc([nH]c1=O)c23 |
| Relative Density. | 1.42 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.2 mg/mL (10.02 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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