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LTA4H-IN-5

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Catalog No. T210386

LTA4H-IN-5 (Compound H122) is an orally active inhibitor of leukotriene A4 hydrolase (LTA4H), effectively suppressing both its aminopeptidase and hydrolase activities with IC50 values of 0.38 nM and 16.93 nM, respectively. In C57 mice, it demonstrates favorable pharmacokinetic properties and shows efficacy in improving DNBS-induced ulcerative colitis in rat models.

LTA4H-IN-5

LTA4H-IN-5

😃Good
Catalog No. T210386
LTA4H-IN-5 (Compound H122) is an orally active inhibitor of leukotriene A4 hydrolase (LTA4H), effectively suppressing both its aminopeptidase and hydrolase activities with IC50 values of 0.38 nM and 16.93 nM, respectively. In C57 mice, it demonstrates favorable pharmacokinetic properties and shows efficacy in improving DNBS-induced ulcerative colitis in rat models.
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Product Introduction

Bioactivity
Description
LTA4H-IN-5 (Compound H122) is an orally active inhibitor of leukotriene A4 hydrolase (LTA4H), effectively suppressing both its aminopeptidase and hydrolase activities with IC50 values of 0.38 nM and 16.93 nM, respectively. In C57 mice, it demonstrates favorable pharmacokinetic properties and shows efficacy in improving DNBS-induced ulcerative colitis in rat models.
Targets&IC50
LTA4H aminopeptidase:0.38 nM, LTA4H aminopeptidase:16.93 nM
Chemical Properties
FormulaC18H17Cl2FN4O4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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