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HER3/ERBB3 Protein, Human, Recombinant

Catalog No. TMPY-00399
Synonyms: LCCS2, c-erbB-3, HER3, p180-ErbB3, erbB3-S, MDA-BF-1, erb-b2 receptor tyrosine kinase 3, c-erbB3, p45-sErbB3, ErbB-3, p85-sErbB3, EEBB3

HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
HER3/ERBB3 Protein, Human, Recombinant
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200 μg In stock $ 583.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.
Species Human
Expression System HEK293 Cells
Tag Tag Free
Accession Number P21860-1
Synonyms LCCS2, c-erbB-3, HER3, p180-ErbB3, erbB3-S, MDA-BF-1, erb-b2 receptor tyrosine kinase 3, c-erbB3, p45-sErbB3, ErbB-3, p85-sErbB3, EEBB3
Construction The Human ERBB3 (NP_001973.2) (Met1-Thr643) was expressed with five amino acids (DDDDK) at the C-terminus.
Protein Purity > 85 % as determined by SDS-PAGE

Molecular Weight 69.3 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

HER3/ERBB3 Protein, Human, Recombinant LCCS2 c-erbB-3 HER3 p180-ErbB3 erbB3-S LCCS-2 EEBB 3 MDA-BF-1 erb-b2 receptor tyrosine kinase 3 c-erbB3 p45-sErbB3 HER-3 ErbB-3 LCCS 2 EEBB-3 p85-sErbB3 EEBB3 HER 3 recombinant recombinant-proteins proteins protein

 

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