FLT3D835Y/F691L-IN-1

Name: FLT3D835Y/F691L-IN-1
Brand: TargetMol
SKU: T209898
Rating: 4.5 (1 reviews)

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Catalog No. T209898

FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor targeting the secondary mutations D835Y/F691L in the FLT3 tyrosine kinase domain, with IC50 values of 1.5 and 9.7 nM, respectively. This compound is applicable in research related to acute myeloid leukemia.

FLT3D835Y/F691L-IN-1

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Catalog No. T209898

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Product Introduction

Bioactivity

Description	FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor targeting the secondary mutations D835Y/F691L in the FLT3 tyrosine kinase domain, with IC50 values of 1.5 and 9.7 nM, respectively. This compound is applicable in research related to acute myeloid leukemia.
In vitro	FLT3D835Y/F691L-IN-1 (0.16-100 nM, 4 h) inhibits the phosphorylation of FLT3 and cell cycle-associated proteins CDK4/6 and Cyclin D3. It also suppresses the proliferation of transfected Ba/F3 cells with FLT3-ITD, FLT3-ITD-D835Y, FLT3-ITD-F691L, FLT3-ITD-D835Y-F691L mutations and the MV4-11 acute myeloid leukemia cell line, with IC50 values of 12.2, 10.5, 24.6, 16.9, and 6.8 nM, respectively.
In vivo	FLT3D835Y/F691L-IN-1, administered orally at a dosage of 30 mg/kg daily for 28 days, effectively reduces tumor volume in mice with Ba/F3-FLT3-ITD-D835Y xenografts.

Chemical Properties

Formula

C₂₆H₃₇N₇O₄

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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