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Ravuconazole

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Catalog No. T7152Cas No. 182760-06-1
Alias ER-30346, BMS-207147

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Ravuconazole

Ravuconazole

😃Good
Purity: 99.84%
Catalog No. T7152Alias ER-30346, BMS-207147Cas No. 182760-06-1
Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$34In StockIn Stock
10 mg$59In StockIn Stock
25 mg$133In StockIn Stock
50 mg$238In StockIn Stock
100 mg$347In StockIn Stock
200 mg$497-In Stock
1 mL x 10 mM (in DMSO)$37In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.84%
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Product Introduction

Bioactivity
Description
Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.
In vitro
The in vitro activity of Ravuconazole against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method.Geometric mean MICs (in microg/ml) were as follows: 1.71 for Ravuconazole, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of concentrations of each drug was 0.125 to >16 microg/ml.Aspergillus fumigatus was significantly more susceptible to Ravuconazole (P < 0.05) than A. terreus and A. flavus.No Ravuconazole-resistant A. fumigatus isolates were identified, though eight itraconazole-resistant (MIC, >8 microg/ml) isolates were.Ravuconazole is active against Aspergillus spp. at slightly high concentrations compared with itraconazole and amphotericin B[1].
SynonymsER-30346, BMS-207147
Chemical Properties
Molecular Weight437.47
FormulaC22H17F2N5OS
Cas No.182760-06-1
SmilesC[C@@H](c1nc(cs1)-c1ccc(cc1)C#N)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
Relative Density.1.38g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (114.29 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.57 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2859 mL11.4294 mL22.8587 mL114.2936 mL
5 mM0.4572 mL2.2859 mL4.5717 mL22.8587 mL
10 mM0.2286 mL1.1429 mL2.2859 mL11.4294 mL
20 mM0.1143 mL0.5715 mL1.1429 mL5.7147 mL
50 mM0.0457 mL0.2286 mL0.4572 mL2.2859 mL
100 mM0.0229 mL0.1143 mL0.2286 mL1.1429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RavuconazoleInhibitorinhibitFungalER30346ER 30346BMS207147BMS 207147Antifungal
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