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Ravuconazole

Name: Ravuconazole
Brand: TargetMol
SKU: T7152
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7152Cas No. 182760-06-1

Alias ER-30346, BMS-207147

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Ravuconazole

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Purity: 99.84%

Catalog No. T7152Alias ER-30346, BMS-207147Cas No. 182760-06-1

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$238	In Stock	In Stock
100 mg	$347	In Stock	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.
In vitro	The in vitro activity of Ravuconazole against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method.Geometric mean MICs (in microg/ml) were as follows: 1.71 for Ravuconazole, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of concentrations of each drug was 0.125 to >16 microg/ml.Aspergillus fumigatus was significantly more susceptible to Ravuconazole (P < 0.05) than A. terreus and A. flavus.No Ravuconazole-resistant A. fumigatus isolates were identified, though eight itraconazole-resistant (MIC, >8 microg/ml) isolates were.Ravuconazole is active against Aspergillus spp. at slightly high concentrations compared with itraconazole and amphotericin B[1].
Synonyms	ER-30346, BMS-207147

Chemical Properties

Molecular Weight	437.47
Formula	C₂₂H₁₇F₂N₅OS
Cas No.	182760-06-1
Smiles	C[C@@H](c1nc(cs1)-c1ccc(cc1)C#N)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
Relative Density.	1.38g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2859 mL	11.4294 mL	22.8587 mL	114.2936 mL
5 mM	0.4572 mL	2.2859 mL	4.5717 mL	22.8587 mL
10 mM	0.2286 mL	1.1429 mL	2.2859 mL	11.4294 mL
20 mM	0.1143 mL	0.5715 mL	1.1429 mL	5.7147 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL	2.2859 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc