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AN3485 Hydrochloride
🥰Excellent
Catalog No. T26626Cas No. 1213786-72-1
Alias AN 3485 Hydrochloride
AN3485 Hydrochloride is a novel anti-inflammatory agent and Toll-like receptor (TLR) inhibitor. It can reduce PMA-induced ear swelling and is used in dermatological research.
AN3485 Hydrochloride
🥰Excellent
Purity: 98.34%
Catalog No. T26626Alias AN 3485 HydrochlorideCas No. 1213786-72-1
AN3485 Hydrochloride is a novel anti-inflammatory agent and Toll-like receptor (TLR) inhibitor. It can reduce PMA-induced ear swelling and is used in dermatological research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Purity:98.34%
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Product Introduction
Bioactivity
Chemical Properties
| Description | AN3485 Hydrochloride is a novel anti-inflammatory agent and Toll-like receptor (TLR) inhibitor. It can reduce PMA-induced ear swelling and is used in dermatological research. |
| Targets&IC50 | TLRs:18-580 nM |
| In vitro | AN3485 Hydrochloride is an inhibitor of Toll-Like Receptors (TLRs) with an IC50 ranging from 18 to 580 nM. [1] |
| In vivo | Oral administration of AN3485 Hydrochloride dose-dependently inhibited LPS-induced TNF-α and IL-6 production in mice with an ED(90) of 30 mg/kg Oral administration of AN3485 Hydrochloride at a dose of 35 mg/kg twice daily was effective in alleviating collagen-induced arthritis symptoms in mice within 20 days. [1] |
| Synonyms | AN 3485 Hydrochloride |
| Molecular Weight | 325.98 |
| Formula | C14H14BCl2NO3 |
| Cas No. | 1213786-72-1 |
| Smiles | Cl.ClC1=CC(=CC=C1OC2=CC=C3C(=C2)B(O)OC3)CN |
| Relative Density. | 1.31g/cm3 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (6.14 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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