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Lusvertikimab
(Synonyms: S-95011, S95011, OSE-127, OSE127) Copy Product Info
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Synonyms: S-95011, S95011, OSE-127, OSE127
Catalog No. T76893 Copy Product Info
Purity: 95%
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Lusvertikimab (OSE-127) is a humanized anti-IL7R antibody with anti-leukemic efficacy that reduces leukemic load in xenograft ALL through antibody-dependent phagocytosis and may be used to study leukemia.
Lusvertikimab
Cas No. 2375835-91-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | In Stock | In Stock | |
| 5 mg | $562 | In Stock | In Stock | |
| 10 mg | $868 | - | In Stock | |
| 25 mg | $1,280 | - | In Stock | |
| 50 mg | $1,730 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.4% (SDS-PAGE); 99% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
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| Description | Lusvertikimab (OSE-127) is a humanized anti-IL7R antibody with anti-leukemic efficacy that reduces leukemic load in xenograft ALL through antibody-dependent phagocytosis and may be used to study leukemia. |
| In vitro | Lusvertikimab inhibits STAT5 phosphorylation in IL7-dependent ALL cell lines and patient-derived xenograft (PDX) samples. [2] |
| In vivo | Lusvertikimab-treated mice exhibited a reduction in peripheral hemoblasts in 95% of the xenograft (PDX) samples when control mice showed overt clinical signs of leukemia. [1] |
| Synonyms | S-95011, S95011, OSE-127, OSE127 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-7R alpha/CD127 Protein (His) (TMPY-01209) at 1 μg/mL (100 μL/well) can bind Lusvertikimab. The EC50 is 7.01 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-7Ra/CD127 |
| Molecular Weight | 145.63 kDa |
| Cas No. | 2375835-91-7 |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Lusvertikimab in vivo | Lusvertikimab in vitro | Lusvertikimab molecular weight
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