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Lusvertikimab
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Catalog No. T76893Cas No. 2375835-91-7
Alias S-95011, S95011, OSE-127, OSE127
Lusvertikimab (OSE-127) is a humanized anti-IL7R antibody with anti-leukemic efficacy that reduces leukemic load in xenograft ALL through antibody-dependent phagocytosis and may be used to study leukemia.
Lusvertikimab
Lusvertikimab
😃Good
Purity: 95%
Catalog No. T76893Alias S-95011, S95011, OSE-127, OSE127Cas No. 2375835-91-7
Lusvertikimab (OSE-127) is a humanized anti-IL7R antibody with anti-leukemic efficacy that reduces leukemic load in xenograft ALL through antibody-dependent phagocytosis and may be used to study leukemia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | In Stock | In Stock | |
| 5 mg | $562 | In Stock | In Stock | |
| 10 mg | $868 | - | In Stock | |
| 25 mg | $1,280 | - | In Stock | |
| 50 mg | $1,730 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.4% (SDS-PAGE); 99% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Target IL-7R
Antibody Information
| Description | Lusvertikimab (OSE-127) is a humanized anti-IL7R antibody with anti-leukemic efficacy that reduces leukemic load in xenograft ALL through antibody-dependent phagocytosis and may be used to study leukemia. |
| In vitro | Lusvertikimab inhibits STAT5 phosphorylation in IL7-dependent ALL cell lines and patient-derived xenograft (PDX) samples. [2] |
| In vivo | Lusvertikimab-treated mice exhibited a reduction in peripheral hemoblasts in 95% of the xenograft (PDX) samples when control mice showed overt clinical signs of leukemia. [1] |
| Synonyms | S-95011, S95011, OSE-127, OSE127 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 2375835-91-7 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | IgG4 (S228P) |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy Lusvertikimab | purchase Lusvertikimab | Lusvertikimab cost | order Lusvertikimab | Lusvertikimab in vivo | Lusvertikimab in vitro
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