Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.
Description | DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment. |
Targets&IC50 | DDR1:7.36 nM (IC50) |
In vitro | DDR1-IN-5 (compound 121), when administered for 24 hours, hampers the production of collagen in human hepatic stellate LX-2 cells, demonstrating an inhibitory concentration (IC 50) of 62 nM[1]. A prolonged exposure of 72 hours to DDR1-IN-5 reveals cytotoxic effects on LX-2 cells, with a cytotoxic concentration (CC 50) exceeding 40 μM[1]. |
Synonyms | DDR1-IN-5 |
Molecular Weight | 434.382 |
Formula | C22H13F3N6O |
CAS No. | 2416022-90-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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DDR1-IN-5 2416022-90-5 DDR-1-IN-5 DDR1IN5 DDR1 IN 5 inhibitor inhibit