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Quinapril hydrochloride

Name: Quinapril hydrochloride
Brand: TargetMol
SKU: T0805
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0805Cas No. 82586-55-8

Alias Quinapril HCl, PD-109452-2, CI-906

Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.

Quinapril hydrochloride

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Purity: 98.05%

Catalog No. T0805Alias Quinapril HCl, PD-109452-2, CI-906Cas No. 82586-55-8

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$38	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$67	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.05%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Quinapril hydrochloride AI Summary

Quinapril hydrochloride exhibits a diverse range of bioactivities. It is known to induce DNA re-replication in normal breast cells, inhibit ATXN expression, and block the entry of the Ebola Virus. It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with varying potencies between 115.8 nM to 39,810.7 nM. The compound significantly inhibits the uptake of sodium fluorescein in OATP1B1- and OATP1B3-transfected CHO cells, showing 109.51% and 98.34% inhibition at 10 µM, respectively. In Vero E6 cells infected with SARS-CoV-2, Quinapril hydrochloride inhibits cell viability with an observed inhibition index of 0.2793 relative to arbidol. Additionally, it demonstrates antimicrobial activity against multiple pathogens, including Candida albicans (3.86%), Escherichia coli (4.26%), Klebsiella pneumoniae (14.37%), Pseudomonas aeruginosa (14.62%), Acinetobacter baumannii (16.28%), and Staphylococcus aureus MRSA (16.74%)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.
Synonyms	Quinapril HCl, PD-109452-2, CI-906

Chemical Properties

Molecular Weight	474.98
Formula	C₂₅H₃₁ClN₂O₅
Cas No.	82586-55-8
Smiles	C1N([C@@H](Cc2ccccc12)C(=O)O)C(=O)[C@H](C)N[C@@H](CCc1ccccc1)C(=O)OCC.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 88 mg/mL (185.27 mM), Sonication is recommended.

H2O: 87 mg/mL (183.17 mM), Sonication is recommended.

DMSO: 65 mg/mL (136.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.1054 mL	10.5268 mL	21.0535 mL	105.2676 mL
5 mM	0.4211 mL	2.1054 mL	4.2107 mL	21.0535 mL
10 mM	0.2105 mL	1.0527 mL	2.1054 mL	10.5268 mL
20 mM	0.1053 mL	0.5263 mL	1.0527 mL	5.2634 mL
50 mM	0.0421 mL	0.2105 mL	0.4211 mL	2.1054 mL
100 mM	0.0211 mL	0.1053 mL	0.2105 mL	1.0527 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc