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Anti-GM130 Polyclonal Antibody 2

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Catalog No. TMAB-06590

Anti-GM130 Polyclonal Antibody 2 is a Rabbit antibody targeting GM130. Anti-GM130 Polyclonal Antibody 2 can be used in WB.

Anti-GM130 Polyclonal Antibody 2

Anti-GM130 Polyclonal Antibody 2

😃Good
Catalog No. TMAB-06590
Anti-GM130 Polyclonal Antibody 2 is a Rabbit antibody targeting GM130. Anti-GM130 Polyclonal Antibody 2 can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-GM130 Polyclonal Antibody 2 is a Rabbit antibody targeting GM130. Anti-GM130 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationGolgi apparatus, Golgi stack membrane; Peripheral membrane protein.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both Giantin and GM130 compete for binding to p115. Thus, p115-Giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and Giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115 and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human GM130
Antigen Species
Human
Gene Name
GOLGA2
Gene ID
2801
Protein Name
Golgin subfamily A member 2
Uniprot ID
Q08379
Function
Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.
Chemical Properties
Molecular WeightTheoretical: 113 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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