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SHP-2 Protein, Mouse, Recombinant (His)
(Synonyms: Syp, SH-PTP3, SH-PTP2, SHP-2, Shp2, SAP-2, PTP2C, PTP1D, protein tyrosine phosphatase, non-receptor type 11, AW536184, 2700084A17Rik) Copy Product InfoSynonyms: Syp, SH-PTP3, SH-PTP2, SHP-2, Shp2, SAP-2, PTP2C, PTP1D, protein tyrosine phosphatase, non-receptor type 11, AW536184, 2700084A17Rik
Catalog No. TMPY-03125 Copy Product Info
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $59 | 7-10 days | 7-10 days | |
| 10 μg | $95 | 7-10 days | 7-10 days | |
| 20 μg | $155 | 7-10 days | 7-10 days | |
| 50 μg | $296 | 7-10 days | 7-10 days | |
| 100 μg | $497 | 7-10 days | 7-10 days | |
| 200 μg | $987 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site . The specific activity is > 1 pmoles/min/μg. |
| Description | SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P35235-2 |
| Construction | A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Met |
| Protein Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 0.1M NaCl, 10% Glycerol, 1 mM TCEP, pH 7.8. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Syp, SH-PTP3, SH-PTP2, SHP-2, Shp2, SAP-2, PTP2C, PTP1D, protein tyrosine phosphatase, non-receptor type 11, AW536184, 2700084A17Rik |
| Research Background |
| Molecular Weight | 69.5 kDa (predicted); 65 kDa (reducing condition, due to glycosylation) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SHP-2 Protein, Mouse, Recombinant (His) chemical structure | SHP-2 Protein, Mouse, Recombinant (His) molecular weight
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