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Anti-GITR/TNFRSF18 Polyclonal Antibody
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Catalog No. TMAB-00771
Alias tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR
Anti-GITR/TNFRSF18 Polyclonal Antibody is a Rabbit antibody targeting GITR/TNFRSF18. Anti-GITR/TNFRSF18 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
Anti-GITR/TNFRSF18 Polyclonal Antibody
Anti-GITR/TNFRSF18 Polyclonal Antibody
😃Good
Catalog No. TMAB-00771Alias tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR
Anti-GITR/TNFRSF18 Polyclonal Antibody is a Rabbit antibody targeting GITR/TNFRSF18. Anti-GITR/TNFRSF18 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Antigen Details
Chemical Properties
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| Description | Anti-GITR/TNFRSF18 Polyclonal Antibody is a Rabbit antibody targeting GITR/TNFRSF18. Anti-GITR/TNFRSF18 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P. |
| Synonyms | tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | Tissue/cell: human oral squamous cell carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-TNFRSF18 Polyclonal Antibody, Unconjugated (TMAB-00771) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. |
| Tissue Specificity | Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells. |
| Immunogen | KLH conjugated synthetic peptide: mouse TNFRSF18 |
| Antigen Species | Mouse |
| Gene Name | TNFRSF18 |
| Gene ID | |
| Protein Name | Tumor necrosis factor receptor superfamily member 18 |
| Uniprot ID | |
| Biology Area | TNF,Regulatory T Cells,Necrosis Factors,TNF |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Molecular Weight | Theoretical: 24 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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