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Foliglurax monohydrochloride

Name: Foliglurax monohydrochloride
Brand: TargetMol
SKU: T11311
Rating: 4.5 (1 reviews)

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Catalog No. T11311Cas No. 2133294-96-7

Alias PXT002331 (monohydrochloride)

Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.

Foliglurax monohydrochloride

😃Good

Catalog No. T11311Alias PXT002331 (monohydrochloride)Cas No. 2133294-96-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$2,170	6-8 weeks	6-8 weeks
25 mg	$3,369	6-8 weeks	6-8 weeks
50 mg	$4,380	6-8 weeks	6-8 weeks
100 mg	$6,100	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.
Targets&IC50	mGlu4:79 nM （EC50）
In vitro	Foliglurax, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders.a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature.
Synonyms	PXT002331 (monohydrochloride)

Chemical Properties

Molecular Weight	457.97
Formula	C₂₃H₂₄ClN₃O₃S
Cas No.	2133294-96-7
Smiles	Cl.O\N=c1/cc(oc2ccc(CCCN3CCOCC3)cc12)-c1cc2sccc2cn1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (10.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1835 mL	10.9177 mL	21.8355 mL	109.1775 mL
5 mM	0.4367 mL	2.1835 mL	4.3671 mL	21.8355 mL
10 mM	0.2184 mL	1.0918 mL	2.1835 mL	10.9177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc