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WNK1-IN-1

🥰Excellent
Catalog No. T73295Cas No. 324022-39-1
Alias WNK1-IN1

WNK1-IN-1 is a selective WNK1 (With No lysine (K) 1) inhibitor (IC50 = 1.6 μM) that inhibits the phosphorylation of the endogenous substrate OSR1, and can be used to study hypertension and cancer.

WNK1-IN-1

WNK1-IN-1

🥰Excellent
Purity: 98.09%
Catalog No. T73295Alias WNK1-IN1Cas No. 324022-39-1
WNK1-IN-1 is a selective WNK1 (With No lysine (K) 1) inhibitor (IC50 = 1.6 μM) that inhibits the phosphorylation of the endogenous substrate OSR1, and can be used to study hypertension and cancer.
Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$163In Stock
10 mg$263In Stock
25 mg$538In Stock
50 mg$868In Stock
100 mg$1,450In Stock
1 mL x 10 mM (in DMSO)$179In Stock
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Purity:98.09%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
WNK1-IN-1 is a selective WNK1 (With No lysine (K) 1) inhibitor (IC50 = 1.6 μM) that inhibits the phosphorylation of the endogenous substrate OSR1, and can be used to study hypertension and cancer.
In vitro
WNK1-IN-1 (0.2-12.5 μM, 24 hours) treats endogenous OSR1 phosphorylated MDAMB231 breast cancer cells with an IC50 value of 4.3 μM. [1]
SynonymsWNK1-IN1
Chemical Properties
Molecular Weight446.14
FormulaC13H15BrCl2N2O4S
Cas No.324022-39-1
Smiles[O-][N+](C1=CC(S(=O)(C(Br)(Cl)Cl)=O)=CC=C1NC2CCCCC2)=O
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (179.32 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2414 mL11.2072 mL22.4145 mL112.0724 mL
5 mM0.4483 mL2.2414 mL4.4829 mL22.4145 mL
10 mM0.2241 mL1.1207 mL2.2414 mL11.2072 mL
20 mM0.1121 mL0.5604 mL1.1207 mL5.6036 mL
50 mM0.0448 mL0.2241 mL0.4483 mL2.2414 mL
100 mM0.0224 mL0.1121 mL0.2241 mL1.1207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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