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Anti-HMGCS2 Polyclonal Antibody
(Synonyms: mitochondrial, Hydroxymethylglutaryl-CoA synthase, HMGCS 2, HMG-CoA synthase, EC 2.3.3.10, 3-hydroxy-3-methylglutaryl coenzyme A synthase) Copy Product Info
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Synonyms: mitochondrial, Hydroxymethylglutaryl-CoA synthase, HMGCS 2, HMG-CoA synthase, EC 2.3.3.10, 3-hydroxy-3-methylglutaryl coenzyme A synthase
Catalog No. TMAB-00874 Copy Product Info
🥰Excellent
Anti-HMGCS2 Polyclonal Antibody is a Rabbit antibody targeting HMGCS2. Anti-HMGCS2 Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P.
Anti-HMGCS2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $222 | 7-10 days | 7-10 days | |
| 100 µL | $374 | 7-10 days | 7-10 days | |
| 200 µL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Liquid
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| Description | Anti-HMGCS2 Polyclonal Antibody is a Rabbit antibody targeting HMGCS2. Anti-HMGCS2 Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P. |
| Synonyms | mitochondrial, Hydroxymethylglutaryl-CoA synthase, HMGCS 2, HMG-CoA synthase, EC 2.3.3.10, 3-hydroxy-3-methylglutaryl coenzyme A synthase |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | Tissue/cell: rat colitis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-HMGCS2 Polyclonal Antibody, Unconjugated (TMAB-00874) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.  |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion. |
| Tissue Specificity | High expression in liver and colon. Low expression in testis, heart, skeletal muscle and kidney. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | HMGCS2 is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | KLH conjugated synthetic peptide: human HMGCS2 |
| Antigen Species | Human |
| Gene Name | HMGCS2 |
| Gene ID | |
| Protein Name | Hydroxymethylglutaryl-CoA synthase, mitochondrial |
| Uniprot ID | |
| Biology Area | Metabolism of lipids and lipoproteins,Cholesterol Metabolism,Cholesterol Metabolism,Lipid metabolism,Mitochondrial markers,Lipid metabolism,Mitochondrial |
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
| Molecular Weight | Theoretical: 52 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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