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yGsy2p-IN-1

Name: yGsy2p-IN-1
Brand: TargetMol
SKU: T8703
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8703Cas No. 2415003-97-1

yGsy2p-IN-1 is a potent inhibitor of yeast glycogen synthase 2 (yGsy2p) and human glycogen synthase 1 (hGYS1). Additionally, yGsy2p-IN-H23, a pyrazole inhibitor, is utilized in the treatment of glycogen storage diseases (GSDs).

yGsy2p-IN-1

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Purity: 99.67%

Catalog No. T8703Cas No. 2415003-97-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$596	In Stock	In Stock
50 mg	$893	In Stock	In Stock
100 mg	$1,250	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

yGsy2p-IN-1 AI Summary

yGsy2p-IN-1 exhibits bioactivity related to the inhibition of glycogen synthase enzymes in both human and rat cells, showing 100% inhibition in respective cell lysates. It inhibits various forms of glycogen synthase enzymes, including recombinant yeast GYS2P and human GYS1, with different inhibition levels measured by IC50 values and enzyme activity assays. Additionally, the compound demonstrates competitive inhibition against human GYS1, highlighting its potential as a modulator of glycogen synthesis processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	yGsy2p-IN-1 is a potent inhibitor of yeast glycogen synthase 2 (yGsy2p) and human glycogen synthase 1 (hGYS1). Additionally, yGsy2p-IN-H23, a pyrazole inhibitor, is utilized in the treatment of glycogen storage diseases (GSDs).
Targets&IC50	GYS1 (WT, human):1.31 µM (Ki), GYS1 (human):2.75 µM (IC50)

Chemical Properties

Molecular Weight	352.26
Formula	C₁₆H₁₁F₃N₂O₄
Cas No.	2415003-97-1
Smiles	Oc1ccc(cc1)-c1c(n[nH]c1C(F)(F)F)-c1ccc(O)c(O)c1O
Relative Density.	1.610 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (177.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8388 mL	14.1941 mL	28.3881 mL	141.9406 mL
5 mM	0.5678 mL	2.8388 mL	5.6776 mL	28.3881 mL
10 mM	0.2839 mL	1.4194 mL	2.8388 mL	14.1941 mL
20 mM	0.1419 mL	0.7097 mL	1.4194 mL	7.0970 mL
50 mM	0.0568 mL	0.2839 mL	0.5678 mL	2.8388 mL
100 mM	0.0284 mL	0.1419 mL	0.2839 mL	1.4194 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc