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MARK-IN-4

Catalog No. T62251 Copy Product Info
Purity: 99.93%
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MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 value of 1 nM. In the pathology of Alzheimer's disease, MARK kinases are responsible for the phosphorylation of Tau protein; hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles and the destabilization of microtubule structures. By potently inhibiting MARK activity, MARK-IN-4 serves as a crucial pharmacological tool for researching the arrest of neurodegenerative disease progression.

MARK-IN-4

Copy Product Info
🥰Excellent
Catalog No. T62251

MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 value of 1 nM. In the pathology of Alzheimer's disease, MARK kinases are responsible for the phosphorylation of Tau protein; hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles and the destabilization of microtubule structures. By potently inhibiting MARK activity, MARK-IN-4 serves as a crucial pharmacological tool for researching the arrest of neurodegenerative disease progression.

MARK-IN-4
Cas No. 1990492-86-8
Pack SizePriceUSA StockGlobal StockQuantity
25 mg$1,520-In Stock
50 mg$1,980-In Stock
100 mg$2,5006-8 weeks6-8 weeks
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:99.93%
Appearance:Solid
Color:Yellow
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 value of 1 nM. In the pathology of Alzheimer's disease, MARK kinases are responsible for the phosphorylation of Tau protein; hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles and the destabilization of microtubule structures. By potently inhibiting MARK activity, MARK-IN-4 serves as a crucial pharmacological tool for researching the arrest of neurodegenerative disease progression.
Targets&IC50
MARK:1 nM
In vitro
MARK-IN-4 potently inhibits MARK kinase (IC50 = 1 nM) and interferes with MAP phosphorylation [1].
Chemical Properties
Molecular Weight421.52
FormulaC21H23N7OS
Cas No.1990492-86-8
SmilesC(N[C@H]1[C@H](N)CCCC1)(=O)C2=CC(C3=C4N(C=C(C=N4)C=5C=NN(C)C5)N=C3)=CS2
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (189.79 mM), Sonication is recommmended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3724 mL11.8618 mL23.7237 mL118.6183 mL
5 mM0.4745 mL2.3724 mL4.7447 mL23.7237 mL
10 mM0.2372 mL1.1862 mL2.3724 mL11.8618 mL
20 mM0.1186 mL0.5931 mL1.1862 mL5.9309 mL
50 mM0.0474 mL0.2372 mL0.4745 mL2.3724 mL
100 mM0.0237 mL0.1186 mL0.2372 mL1.1862 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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