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TAS4464

Name: TAS4464
Brand: TargetMol
SKU: T13090L
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T13090LCas No. 1848959-10-3

TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).

TAS4464

🥰Excellent

Purity: 98.27%

Catalog No. T13090LCas No. 1848959-10-3

TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Purity:98.27%

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Product Introduction

Bioactivity

Description	TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
Targets&IC50	NAE:0.955 nM
In vitro	TAS4464 treatment inhibits cullin neddylation, leading to the accumulation of CRL substrates including CDT1, p27, and phosphorylated IκBα in 47 human cancer cell lines.

Chemical Properties

Molecular Weight	506.51
Formula	C₂₁H₂₃FN₆O₆S
Cas No.	1848959-10-3
Smiles	CCOc1cccc(F)c1C#Cc1cn([C@@H]2O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Relative Density.	1.66 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (246.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.52 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9743 mL	9.8715 mL	19.7429 mL	98.7147 mL
5 mM	0.3949 mL	1.9743 mL	3.9486 mL	19.7429 mL
10 mM	0.1974 mL	0.9871 mL	1.9743 mL	9.8715 mL
20 mM	0.0987 mL	0.4936 mL	0.9871 mL	4.9357 mL
50 mM	0.0395 mL	0.1974 mL	0.3949 mL	1.9743 mL
100 mM	0.0197 mL	0.0987 mL	0.1974 mL	0.9871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc