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AR-C126313

Name: AR-C126313
Brand: TargetMol
SKU: T30120
Price: 153 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ARC126313, AR-C118925XX, ARC118925XX, ARC 118925XX, AR C126313) Copy Product Info

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Synonyms: ARC126313, AR-C118925XX, ARC118925XX, ARC 118925XX, AR C126313

Catalog No. T30120 Copy Product Info

Purity: 99.44%

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AR-C126313 is a selective P2Y2 receptor antagonist that inhibits ATP-mediated signaling pathways. In cell and animal models, AR-C126313 can modulate inflammation-related signaling, such as IL-6 production and p38 MAPK phosphorylation, and has been used to study fibrosis and tumor-related processes under specific experimental conditions.

Cas No. 216657-60-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$153	-	In Stock
5 mg	$356	-	In Stock
10 mg	$571	-	In Stock
25 mg	$1,160	-	In Stock
50 mg	$1,860	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.44%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AR-C126313 is a selective P2Y2 receptor antagonist that inhibits ATP-mediated signaling pathways. In cell and animal models, AR-C126313 can modulate inflammation-related signaling, such as IL-6 production and p38 MAPK phosphorylation, and has been used to study fibrosis and tumor-related processes under specific experimental conditions.
In vivo	AR-C126313 inhibits the increase in dermal thickness induced by bleomycin in mice [1].
Synonyms	ARC126313, AR-C118925XX, ARC118925XX, ARC 118925XX, AR C126313

Chemical Properties

Molecular Weight	537.59
Formula	C₂₈H₂₃N₇O₃S
Cas No.	216657-60-2
Smiles	O=C(NC1=NN=NN1)C=2OC(=CC2)CN3C=C(C(=S)NC3=O)C4C5=CC=C(C=C5C=CC6=CC(=CC=C64)C)C
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (148.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8602 mL	9.3008 mL	18.6015 mL	93.0077 mL
5 mM	0.3720 mL	1.8602 mL	3.7203 mL	18.6015 mL
10 mM	0.1860 mL	0.9301 mL	1.8602 mL	9.3008 mL
20 mM	0.0930 mL	0.4650 mL	0.9301 mL	4.6504 mL
50 mM	0.0372 mL	0.1860 mL	0.3720 mL	1.8602 mL
100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.9301 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.